Cisapride Pharmacodynamics

In abounding countries (including Canada) cisapride has been either aloof or has had its break bound due to letters about continued QT affection due to cisapride, which predisposes to arrhythmias. The FDA issued a admonishing letter apropos this accident to bloom affliction professionals and patients.

Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Dispatch of the serotonin receptors increases acetylcholine absolution in the enteric afraid system. Cisapride stimulates action of the high gastrointestinal amplitude after aesthetic gastric, biliary, or pancreatic secretions. Cisapride increases the accent and amplitude of belly (especially antral) contractions, relaxes the pyloric sphincter and the belly bulb, and increases peristalsis of the duodenum and jejunum consistent in accelerated belly elimination and abdominal transit. It increases the comatose accent of the lower esophageal sphincter. It has little, if any, aftereffect on the action of the colon or gallbladder. Cisapride does not abet muscarinic or nicotinic receptor stimulation, nor does it arrest acetylcholinesterase activity.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s