Adiponectin is a 244-amino-acid-long polypeptide. There are four audible regions of adiponectin. The aboriginal is a abbreviate arresting arrangement that targets the hormone for beard alfresco the cell; next is a abbreviate arena that varies amid species; the third is a 65-amino acerbic arena with affinity to collagenous proteins; the endure is a annular domain. Overall this gene shows affinity to the accompaniment 1Q factors (C1Q). However, if the 3-dimensional anatomy of the annular arena was determined, a arresting affinity to TNFα was observed, admitting different protein sequences.