Daptomycin Indications

Daptomycin has action adjoin the following:

Gram-positive bacilli (broad-spectrum activity)

Multidrug-resistant gram-positive bacilli (because cross-resistance with added classes of antibiotics does not occur)

Daptomycin is acclimated mainly for infections acquired by

Vancomycin- and methicillin-resistant Staphylococcus aureus

Vancomycin-resistant enterococci

Pneumococci with bargain penicillin sensitivity

However, methicillin-resistant S. aureus and vancomycin-resistant enterococci may become aggressive during daptomycin therapy, consistent in relapsing or assiduous infection.

Daptomycin is inferior to ceftriaxone for pneumonia, apparently because daptomycin can bind to pulmonary surfactant, abbreviation daptomycin’s action in the alveolar epithelial lining fluid.

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