Hydrocortisone Mechanism of Action

Hydrocortisone binds to the cytosolic glucocorticoid receptor. After bounden the receptor the anew formed receptor-ligand circuitous translocates itself into the corpuscle nucleus, area it binds to abounding glucocorticoid acknowledgment elements (GRE) in the apostle arena of the ambition genes. The DNA apprenticed receptor again interacts with basal archetype factors, causing the access in announcement of specific ambition genes. The anti-inflammatory accomplishments of corticosteroids are anticipation to absorb lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, ascendancy the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids abet lipocortin-1 (annexin-1) synthesis, which again binds to corpuscle membranes preventing the phospholipase A2 from advancing into acquaintance with its substrate arachidonic acid. This leads to beneath eicosanoid production. The cyclooxygenase (both COX-1 and COX-2) announcement is aswell suppressed, potentiating the effect. In added words, the two capital articles in deepening Prostaglandins and Leukotrienes are inhibited by the activity of Glucocorticoids. Glucocorticoids aswell activate the lipocortin-1 artifice to the extracellular space, area it binds to the corpuscle film receptors and inhibits assorted anarchic events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory access and the absolution of assorted anarchic mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the allowed arrangement is suppressed by corticosteroids due to a abatement in the action of the aqueous system, a abridgement in immunoglobulin and accompaniment concentrations, the precipitation of lymphocytopenia, and arrest with antigen-antibody binding.


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