The above use of chlorobenzene is as an average in the assembly of bolt such as herbicides, dyestuffs, and rubber. Chlorobenzene is aswell acclimated as a high-boiling bread-and-butter in abounding automated applications as able-bodied as in the laboratory. Chlorobenzene is nitrated on a ample calibration to accord a admixture of 2-nitrochlorobenzene and 4-nitrochlorobenzene , which are separated. These mononitrochlorobenzenes are adapted to accompanying 2-nitrophenol, 2-nitroanisole, bis(2-nitrophenyl)disulfide, and 2-nitroaniline by nucleophilic displacement of the chloride, with appropriately sodium hydroxide, sodium methoxide, sodium disulfide, and ammonia. The conversions of the 4-nitro acquired are similar.
Chlorobenzene already was acclimated in the accomplish of assertive pesticides, a lot of conspicuously DDT by acknowledgment with chloral (trichloroacetaldehyde), but this appliance has beneath with the beneath use of DDT. At one time, chlorobenzene was the capital forerunner for the accomplish of phenol:
C6H5Cl + NaOH → C6H5OH + NaCl
The reaction also has a byproduct of salt.