During the changeable aeon (the access of adolescence through to menopause), abundant of the estradiol is produced by the granulosa beef in the ovaries through aromatization of androstenedione. The androstenedione is produced by the folliculi cells. This is again adapted to estrone, which is adapted to estradiol by the agitator 17β-hydroxysteroid dehydrogenase. In men, a baby bulk of estradiol is produced by the testes.
As able-bodied as getting produced by the gonads, in both genders fat beef aftermath alive estradiol precursors, even in women who accept gone through the menopause. Baby amounts of estradiol are aswell produced in the academician and arterial walls.
Estradiol acts primarily as a advance hormone for the changeable structures including the lining of the vagina, the fallopian tubes, the endometrium and the cervical glands. The hormone is aswell appropriate to advance oocytes (eggs in the ovary) and triggers a alternation of contest that advance to ovulation. In addition, estradiol works in affiliation with progesterone to adapt the abyss lining for implantation. In males, estradiol aids agent maturation and aswell helps to advance a advantageous libido.