Cisapride Pharmacodynamics

In abounding countries (including Canada) cisapride has been either aloof or has had its break bound due to letters about continued QT affection due to cisapride, which predisposes to arrhythmias. The FDA issued a admonishing letter apropos this accident to bloom affliction professionals and patients.

Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Dispatch of the serotonin receptors increases acetylcholine absolution in the enteric afraid system. Cisapride stimulates action of the high gastrointestinal amplitude after aesthetic gastric, biliary, or pancreatic secretions. Cisapride increases the accent and amplitude of belly (especially antral) contractions, relaxes the pyloric sphincter and the belly bulb, and increases peristalsis of the duodenum and jejunum consistent in accelerated belly elimination and abdominal transit. It increases the comatose accent of the lower esophageal sphincter. It has little, if any, aftereffect on the action of the colon or gallbladder. Cisapride does not abet muscarinic or nicotinic receptor stimulation, nor does it arrest acetylcholinesterase activity.