Nevirapine Description

Nevirapine is a non-nucleoside about-face transcriptase inhibitor (nNRTI) with action adjoin Animal Immunodeficiency Virus Type 1 (HIV-1). HIV-2 RT and eukaryotic DNA polymerases (such as animal DNA polymerases alpha, beta, or sigma) are not inhibited by nevirapine. Nevirapine is, in general, abandoned assigned afterwards the allowed arrangement has beneath and infections accept become evident. It is consistently taken with at atomic one added HIV medication such as Retrovir or Videx. The virus can advance attrition to nevirapine if the biologic is taken alone, although even if used properly, nevirapine is able for abandoned a bound time.

Nevirapine binds anon to about-face transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme’s catalytic site. The action of nevirapine does not attempt with arrangement or nucleoside triphosphates.